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Current research projects in the laboratory: *Cardiac Kv7.1 potassium channels: structure, gating mechanisms, thermodynamics and implications for diseased cardiac long QT mutations. *Brain Kv7.2/3 potassium channels: neurophysiology, homeostatic plasticity.
Using the powerful combination of electrophysiology, cell biophysics, molecular biology and biochemistry, we study the properties of a family of voltage-gated potassium channel proteins, Kv7 (KCNQ), whose mutations in humans lead to major neurological and