14 Feb Intern in Ion Channel Training
internship0001508 Tel Aviv University-Sackler Faculty of Medicine
Using the powerful combination of electrophysiology, cell biophysics, molecular biology and biochemistry, we study the properties of a family of voltage-gated potassium channel proteins, Kv7 (KCNQ), whose mutations in humans lead to major neurological and cardiovascular disorders like epilepsy, deafness and cardiac arrhythmias (long QT syndrome). Our research aims at elucidating the structural, biophysical and physiological characteristics of neuronal and cardiac Kv7 channels.
Current research projects in the laboratory: *Cardiac Kv7.1 potassium channels: structure, gating mechanisms, thermodynamics and implications for diseased cardiac long QT mutations. *Brain Kv7.2/3 potassium channels: neurophysiology, homeostatic plasticity at the axon initial segment and implications for epileptic encephalopathy mutations. *Mechanisms underlying the cardiac pacemaker activity in normal and diseased arrhythmic conditions using human induced-pluripotent stem cell-derived cardiomyocytes and mouse animal models. *Targeting the voltage sensor of Kv7 and TRPV1 channels with gating-modifier molecules.
Good background in physiology and biology
no special requirement